What is the Difference Between Chromosome and Chromatid?

Difference between Chromosome and Chromatid

Genetics is the study of heredity in living organisms. One of the most crucial topics in genetics is the study of the genetic material, the DNA.

Due to their usage, the two terms, “chromosome” and “chromatid” are often confused with each other. While seemingly identical at first glance, these biological structures for genetic information are not the same entities.

How do they differ? Let’s explore the difference between Chromosome and Chromatid in detail below.

What is a Chromosome?

Coming from the Greek words “chroma” and “soma” which mean “color” and “body” respectively, a chromosome is a coiled thread-like structure that contains the genetic material of organisms. A chromosome is the condensed form of a chromatin, which in turn is made up of the deoxyribonucleic acid (also known as DNA) and proteins called histones.

Depending on the type of organism, the chromosome number differs. Some organisms can have one chromosome, while some organisms can have up to hundreds!

  • The genetic material of prokaryotic organisms is contained in one chromosome, whereas eukaryotic organisms have theirs in multiple chromosomes. [Examples: Jack jumper ant (venomous ant native to Australia) has 1 chromosome; Atlas blue butterfly (found in North Africa) has 448-452 chromosomes].
  • Jack Jumper Ant / Atlas Blue Butterfly

  • In humans, the chromosomes for every cell in the body have identical pairs, except for the sex chromosomes X and Y. The X chromosome is a relatively larger chromosome with more genes, making the genes more dominant. On the other hand, the Y chromosome is responsible for exhibiting “maleness” and manifesting male sexual traits.

What is a Chromatid?

By definition, a chromatid is one of the two identical components that make up a duplicated chromosome. As such, the chromosome is said to be composed of identical sister chromatids.

  • Chromatids (sister) are formed after the chromatin condenses during metaphase. These structures are then joined together in the central region by a structure called the centromere. Shortly after, these sister chromatids will separate during the anaphase as they move to the opposite poles of the cell.
  • It is important to note that chromatids cannot be considered as “sister” unless the centromere holds them together.
  • During the onset of cell division, the aim is to form cells capable of both function and reproduction; the chromatid is the structure that ensures that this process occurs correctly.

Difference Between Chromosome and Chromatid

The table below summarizes the two’s major differences in structure and function.

Chromosome Chromatid
Occurrence Occurs throughout the cell’s life cycle. Created only when the cell undergoes mitosis or meiosis.
Structure Tightly packed DNA. Unwound DNA.
Exact copies of each other? No. Homologous chromosomes can have different forms of trait; one copy of the gene comes from each parent. Yes, each sister chromatid is an exact copy of each other.
Duplicated? Yes No
Has Centromere? Yes None (however, sister chromatids have centromeres).
Function Carries the genetic material. Enables cells to duplicate.
Macromolecule Synthesis DNA is not being used. DNA is being used.

Here is the visual explanation describing the more detailed differences.

The chromosomes and chromatids have acquired unique biology shaped by evolution through time. The study of these differences will give greater insights into the process’s evolution and consequences.

Cite This Page

BioExplorer.net. (2023, November 29). What is the Difference Between Chromosome and Chromatid?. Bio Explorer. https://www.bioexplorer.net/difference-between-chromosome-and-chromatid.html/.
BioExplorer.net. "What is the Difference Between Chromosome and Chromatid?" Bio Explorer, 29 November 2023, https://www.bioexplorer.net/difference-between-chromosome-and-chromatid.html/.
BioExplorer.net. "What is the Difference Between Chromosome and Chromatid?" Bio Explorer, November 29 2023. https://www.bioexplorer.net/difference-between-chromosome-and-chromatid.html/.
Key References
  • “Chromosomes Fact Sheet – National Human Genome Research Institute (NHGRI)”. Accessed September 15, 2017. Link.
  • “Chromosomes and Chromatin – The Cell – NCBI Bookshelf”. Accessed September 15, 2017. Link.
  • “Chromosomes: Definition & Structure”. Accessed September 15, 2017. Link.
  • “Chromatid – National Library of Medicine – PubMed Health”. Accessed September 15, 2017. Link.



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