Biophysics is an inter-disciplinary science using methods and theories from physics to study biological systems. Biophysics spans all scales of biological organization, from the molecular scale to whole organisms and ecosystems.
Crystallization of protein-nucleic acid complexes
A prerequisite for the determination of the three-dimensional structure of a protein-nucleic acid complex by x-ray crystallography is a well-ordered crystal of the complex in question. This article describes methods for crystallizing these complexes, including protein sample, choice of oligonucleotide, preparation of complexes, and crystallization conditions.
